1 00:00:00,695 --> 00:00:01,921 Previously on PURE GENIUS... 2 00:00:01,992 --> 00:00:03,085 When I opened bunker hill 3 00:00:03,147 --> 00:00:05,103 I made a promise that I would do 4 00:00:05,134 --> 00:00:07,031 everything humanly possible to save 5 00:00:07,085 --> 00:00:08,538 everyone who came through these doors. 6 00:00:08,562 --> 00:00:09,757 I want to be part of this. 7 00:00:09,782 --> 00:00:10,795 Bell: Julianna Wallace, 8 00:00:10,820 --> 00:00:11,929 executive consumer 9 00:00:11,960 --> 00:00:13,445 safety officer for the FDA. 10 00:00:13,492 --> 00:00:14,945 You married up, W. 11 00:00:16,189 --> 00:00:18,123 - You kissed me. - Really? 12 00:00:18,851 --> 00:00:20,195 Cheng: This is Louis Keating. 13 00:00:20,249 --> 00:00:21,405 He's been diagnosed with gerstmann- 14 00:00:21,429 --> 00:00:22,406 Straussler-Scheinker disease. 15 00:00:22,449 --> 00:00:24,015 Bell: It's like als on steroids. 16 00:00:24,080 --> 00:00:26,007 I did have the genetic test done, 17 00:00:26,088 --> 00:00:27,953 and it came back positive for GSS. 18 00:00:28,073 --> 00:00:29,940 I'm so sorry, James. 19 00:00:30,569 --> 00:00:32,637 ♪ ♪ 20 00:00:39,094 --> 00:00:42,124 ♪ Do you feel electric in your ♪ 21 00:00:42,202 --> 00:00:44,124 ♪ Hands and legs? ♪ 22 00:00:44,257 --> 00:00:46,874 ♪ I sense the gravity shifting ♪ 23 00:00:46,876 --> 00:00:49,311 ♪ Inside our heads ♪ 24 00:00:49,413 --> 00:00:52,458 ♪ All the thoughts go up ♪ 25 00:00:52,528 --> 00:00:55,200 ♪ Never settle down ♪ 26 00:00:55,302 --> 00:00:57,989 ♪ In these chaos caves ♪ 27 00:00:58,083 --> 00:01:01,462 ♪ No relief to be found ♪ 28 00:01:01,516 --> 00:01:03,165 ♪ Working on ♪ 29 00:01:03,251 --> 00:01:06,307 ♪ The appetite till dawn ♪ 30 00:01:06,362 --> 00:01:08,714 ♪ Burning forests, forests ♪ 31 00:01:08,798 --> 00:01:11,832 ♪ How long till they're all gone? ♪ 32 00:01:11,833 --> 00:01:14,807 ♪♪ 33 00:01:14,846 --> 00:01:17,885 ♪♪ 34 00:01:18,003 --> 00:01:20,464 ♪ I feel you move me ♪ 35 00:01:20,550 --> 00:01:25,223 ♪ To another world... ♪ 36 00:01:25,317 --> 00:01:28,028 ♪ We fly ♪ 37 00:01:28,090 --> 00:01:31,680 ♪ Over mountains and ride ♪ 38 00:01:31,805 --> 00:01:33,234 ♪ Through the sunset ♪ 39 00:01:33,297 --> 00:01:35,195 ♪ I'm just so excited ♪ 40 00:01:35,273 --> 00:01:39,856 ♪ When I got you by my side. ♪ 41 00:01:39,881 --> 00:01:40,931 (Laughs) 42 00:01:41,059 --> 00:01:43,481 This is Madeline Sorenson from Wichita, Kansas. 43 00:01:43,543 --> 00:01:46,645 She's 15 years old... high-risk acute Myeloid Leukemia. 44 00:01:46,739 --> 00:01:48,317 Terminal. 45 00:01:48,457 --> 00:01:51,332 She's been everywhere. I've checked her scans and her history. 46 00:01:51,449 --> 00:01:52,942 Unfortunately, James, there's not much 47 00:01:53,002 --> 00:01:54,301 we can do for this patient. 48 00:01:54,375 --> 00:01:56,754 Well, what about... Car T-Cell therapy? 49 00:01:56,856 --> 00:01:58,300 It's brand-new, and we've been given approval 50 00:01:58,324 --> 00:02:00,567 for a one-time trial through the FDA's compassionate use program. 51 00:02:00,591 --> 00:02:01,926 Cytotoxic T-Cells. 52 00:02:01,984 --> 00:02:03,361 The green berets of our immune system. 53 00:02:03,385 --> 00:02:05,379 Exactly. James, it's shown a lot of promise 54 00:02:05,434 --> 00:02:07,942 in fighting Lymphoid-type blood cancers, but this type 55 00:02:08,004 --> 00:02:10,652 of Leukemia, it's a different beast altogether. 56 00:02:10,723 --> 00:02:13,012 Unfortunately, T-Cells don't have antibody detectors 57 00:02:13,082 --> 00:02:16,074 that fit into a protein on the surface of the Leukemia cell. 58 00:02:16,215 --> 00:02:19,400 Which is why we're... Gonna engineer one. 59 00:02:19,455 --> 00:02:21,486 Well, we'd have to design a very specific key, 60 00:02:21,541 --> 00:02:22,770 which could take time. 61 00:02:22,845 --> 00:02:24,665 And her latest labs are not good. 62 00:02:24,743 --> 00:02:26,970 Hemoglobin: 5.8; Platelets: 64. 63 00:02:27,071 --> 00:02:29,001 She has a month, maybe two at best. 64 00:02:29,044 --> 00:02:31,110 Okay, I get it, it's a hail Mary pass, but... 65 00:02:31,188 --> 00:02:32,788 Before I hear all the naysayers speak up, 66 00:02:32,815 --> 00:02:34,688 let me remind you of two things. 67 00:02:34,874 --> 00:02:36,741 This face. 68 00:02:37,918 --> 00:02:40,319 And it's Christmas week. 69 00:02:41,829 --> 00:02:44,525 Okay, Naysayers, Speaketh. 70 00:02:47,579 --> 00:02:49,963 Yeah. Let's bring her in. 71 00:02:51,040 --> 00:02:52,305 Why not? 72 00:02:53,954 --> 00:02:55,946 Tina, send the plane for Maddie and her family. 73 00:02:55,977 --> 00:02:57,743 And Merry Christmas, everyone. 74 00:02:58,026 --> 00:02:58,925 And, Rebecca, 75 00:02:58,970 --> 00:03:00,837 - Happy Chanukah. - Shalom. 76 00:03:00,976 --> 00:03:02,509 And... 77 00:03:02,930 --> 00:03:04,079 Christian. 78 00:03:04,130 --> 00:03:06,630 So we're all covered. Good. Carry on. 79 00:03:10,493 --> 00:03:12,152 Dr. Verlaine. 80 00:03:12,727 --> 00:03:13,964 May I have a word? 81 00:03:13,989 --> 00:03:15,022 Yes. 82 00:03:15,024 --> 00:03:17,305 (Whispers): Um... About that kiss. 83 00:03:17,393 --> 00:03:19,337 - (Whispers): What kiss? - Our kiss. 84 00:03:19,399 --> 00:03:21,016 - A few weeks ago. - I'm joking. 85 00:03:21,110 --> 00:03:24,134 (Laughs): Oh. Right. Hmm. 86 00:03:24,270 --> 00:03:25,736 It's amusing. 87 00:03:25,829 --> 00:03:27,743 So, as I said, I was sleep-deprived, 88 00:03:27,826 --> 00:03:30,196 I wasn't thinking straight, and we had just attended 89 00:03:30,259 --> 00:03:31,766 a wedding... - Look, I hear it. 90 00:03:31,876 --> 00:03:33,002 - Let's just forget - that it ever hap... 91 00:03:33,026 --> 00:03:35,876 But upon further review, I realize it was not 92 00:03:35,977 --> 00:03:38,595 entirely fair to make you feel like it was all one-sided, 93 00:03:38,662 --> 00:03:40,438 so I take... 94 00:03:40,532 --> 00:03:42,438 Some responsibility for what happened. 95 00:03:42,477 --> 00:03:44,218 Look, Brockett, 96 00:03:44,290 --> 00:03:46,493 it's kind of hard to have a conversation here. 97 00:03:46,626 --> 00:03:48,782 - Mm-hmm. - What if we grab dinner off campus? 98 00:03:48,860 --> 00:03:51,266 Din... dinner? 99 00:03:51,548 --> 00:03:52,813 Yeah. 100 00:03:52,928 --> 00:03:55,262 - Talk this through. - I'll do brunch. 101 00:03:55,264 --> 00:03:56,657 (Chuckles) 102 00:03:56,915 --> 00:03:57,931 brunch works. 103 00:03:57,933 --> 00:04:01,423 Okay. Good. Thank you, Dr. Verlaine. 104 00:04:01,532 --> 00:04:03,516 Dr. Brockett. 105 00:04:03,930 --> 00:04:05,399 Woman: You see this woman? 106 00:04:05,493 --> 00:04:06,845 Andrea Cocciano. 107 00:04:06,930 --> 00:04:08,485 Born Andrew Cocciano. 108 00:04:08,665 --> 00:04:09,946 She identified as a woman 109 00:04:10,009 --> 00:04:11,415 from the time she was six years old. 110 00:04:11,513 --> 00:04:13,876 She's brilliant. MBA from Harvard. 111 00:04:14,087 --> 00:04:15,595 And she's about to be fired 112 00:04:15,665 --> 00:04:18,376 by a major equities firm because she's transgender. 113 00:04:18,501 --> 00:04:20,188 This is a precedent-setting case 114 00:04:20,259 --> 00:04:22,548 of national importance. I can win this. 115 00:04:22,641 --> 00:04:24,727 But I need your help to cure me first. 116 00:04:24,930 --> 00:04:27,116 We are well aware of your work as a civil rights attorney. 117 00:04:27,140 --> 00:04:28,707 I have to admit, I'm a fan. 118 00:04:28,732 --> 00:04:30,999 Thank you. Okay, let's talk quickly, 119 00:04:31,033 --> 00:04:33,022 'cause I'm a ticking time bomb. 120 00:04:33,147 --> 00:04:35,002 I wasn't diagnosed until six months ago. 121 00:04:35,140 --> 00:04:37,054 The theory is I've had these petit mal seizures 122 00:04:37,124 --> 00:04:38,679 my whole life. As a child, 123 00:04:38,741 --> 00:04:40,772 they would come and go, but they never affected me. 124 00:04:40,850 --> 00:04:41,827 Now I have an average 125 00:04:41,853 --> 00:04:43,119 of ten per hour. 126 00:04:43,421 --> 00:04:44,827 I can't go to trials like this. 127 00:04:44,852 --> 00:04:47,350 I can barely even get through a deposition at this point. 128 00:04:47,398 --> 00:04:48,811 I need someone to take the bull 129 00:04:48,874 --> 00:04:51,015 by the horns or I am out of business. 130 00:04:51,085 --> 00:04:53,168 And so are all the people who are depending on me 131 00:04:53,233 --> 00:04:55,670 to feel heard and represented. 132 00:04:57,507 --> 00:05:00,008 (Teeth clicking, scraping) 133 00:05:05,181 --> 00:05:06,725 (Clicking and scraping stop) 134 00:05:12,335 --> 00:05:14,366 It just happened, didn't it? 135 00:05:15,265 --> 00:05:16,365 Wallace: Let's give him 136 00:05:16,406 --> 00:05:18,907 another course of gent and make sure to monitor his creatinine. 137 00:05:18,972 --> 00:05:20,338 - Yes, doctor. - Thank you. 138 00:05:20,340 --> 00:05:22,061 Merry Christmas, Dr. Wallace. 139 00:05:22,086 --> 00:05:23,054 Honey. 140 00:05:23,100 --> 00:05:24,753 Yes, it is. (Laughs) 141 00:05:24,838 --> 00:05:27,050 - What-what are you doing here? - Oh, well, 142 00:05:27,108 --> 00:05:29,644 I know that you only had two days over Christmas, 143 00:05:29,746 --> 00:05:31,582 so I... played around with my schedule. 144 00:05:31,584 --> 00:05:33,792 I don't want you to be alone over the holidays. 145 00:05:33,839 --> 00:05:35,612 This is a wonderful surprise. 146 00:05:35,637 --> 00:05:36,760 And don't worry, 147 00:05:36,786 --> 00:05:38,081 I brought plenty of my own work. 148 00:05:38,106 --> 00:05:40,707 In fact, some of it is, uh, right here. 149 00:05:40,994 --> 00:05:42,059 Here? Yeah, bunker hill 150 00:05:42,061 --> 00:05:44,348 has a request to, uh, approve 151 00:05:44,430 --> 00:05:46,898 a trial for a drug for GSS... Gerstmann-Straussler- 152 00:05:46,900 --> 00:05:48,945 Scheinker Syndrome. - I know about the trial. 153 00:05:49,000 --> 00:05:50,323 I would normally have somebody else 154 00:05:50,347 --> 00:05:52,758 at the office do it, but I pulled a few strings 155 00:05:52,893 --> 00:05:54,626 and here I am. Well, we're gonna have 156 00:05:54,705 --> 00:05:56,805 a wonderful holiday. - BFF! 157 00:05:56,943 --> 00:05:58,550 What on earth are you doing here? 158 00:05:58,611 --> 00:05:59,888 (Laughs): Hi, James. 159 00:05:59,913 --> 00:06:01,128 Are you here for business or pleasure? 160 00:06:01,152 --> 00:06:02,448 Actually, I'm here 161 00:06:02,520 --> 00:06:04,682 for the presentation on the GSS trial. 162 00:06:04,901 --> 00:06:06,386 Oh. 163 00:06:06,411 --> 00:06:07,370 Wonderful. Didn't know the FDA 164 00:06:07,416 --> 00:06:08,949 would send out the big guns 165 00:06:09,022 --> 00:06:10,417 for our tiny little study. 166 00:06:10,487 --> 00:06:12,023 May I borrow your husband 167 00:06:12,025 --> 00:06:13,050 for just a moment? 168 00:06:13,075 --> 00:06:14,123 - Sure. - Yeah. 169 00:06:14,124 --> 00:06:15,659 Perseus, would you help Julianna 170 00:06:15,715 --> 00:06:17,143 with her luggage? - I'll take your bags for you. 171 00:06:17,167 --> 00:06:18,136 Oh, thank you. 172 00:06:18,175 --> 00:06:19,741 Wish you'd mentioned that the grim reaper 173 00:06:19,765 --> 00:06:21,831 was coming here to ruin our GSS trial. 174 00:06:21,940 --> 00:06:24,018 I was expecting to get someone lower on the food chain 175 00:06:24,042 --> 00:06:26,437 so I could push it through. I had no idea she was coming. 176 00:06:26,439 --> 00:06:28,855 But don't call her that the grim reaper, even if it's a joke. 177 00:06:28,885 --> 00:06:31,283 - I felt it, W. - You felt what? 178 00:06:31,525 --> 00:06:33,087 The tremor. What kind of tremor? 179 00:06:33,150 --> 00:06:34,749 A not particularly distinguishable tremor 180 00:06:34,773 --> 00:06:36,003 in my right hand. Tremors are typically 181 00:06:36,004 --> 00:06:37,540 the first signs of the symptoms of GSS 182 00:06:37,565 --> 00:06:39,032 taking a hold on the human body. James... 183 00:06:39,056 --> 00:06:40,706 Mild tremors followed by more intense tremors 184 00:06:40,730 --> 00:06:42,430 followed by TICs to slowing of the muscles 185 00:06:42,532 --> 00:06:44,572 to attacking and eventually destroying of the brain. 186 00:06:44,634 --> 00:06:46,626 (Whispers): I felt it, W. 187 00:06:46,726 --> 00:06:48,249 I don't want you to jump to any conclusion... 188 00:06:48,273 --> 00:06:49,781 W... 189 00:06:51,282 --> 00:06:53,149 Will you be my doctor? 190 00:06:53,399 --> 00:06:54,883 Of course. 191 00:06:56,782 --> 00:06:58,402 Excellent. 192 00:06:58,790 --> 00:07:01,079 Ah, here she is. 193 00:07:01,274 --> 00:07:03,157 You must be Maddie. 194 00:07:03,423 --> 00:07:05,548 You must be James Bell. 195 00:07:05,708 --> 00:07:07,680 Hi. I'm Dr. Wallace. Nice to meet you all. 196 00:07:07,788 --> 00:07:09,719 Hi. Thank you so much for accepting 197 00:07:09,771 --> 00:07:11,400 our application. - Nice to meet you. 198 00:07:12,424 --> 00:07:14,418 Are you ready to kick your cancer's ass? 199 00:07:14,627 --> 00:07:16,127 So ready. 200 00:07:16,362 --> 00:07:17,846 Let's get you checked in. 201 00:07:18,757 --> 00:07:20,807 Welcome to Bunker Hill. 202 00:07:24,495 --> 00:07:26,262 Right this way. 203 00:07:26,286 --> 00:07:28,518 ♪♪ 204 00:07:28,600 --> 00:07:31,986 ♪ ♪ *PURE GENIUS* Season 01 Episode 07 "A Bunker Hill Christmas" Synchronized by srjanapala 205 00:07:34,577 --> 00:07:37,505 Today we have proven that this Public Elementary School 206 00:07:37,692 --> 00:07:39,927 knowingly put its own students' health at risk 207 00:07:39,974 --> 00:07:43,802 by using a food vendor that provided absolutely zero 208 00:07:43,971 --> 00:07:46,669 food choices that met with FDA nutritional standards. 209 00:07:46,778 --> 00:07:49,083 And the court ruling today comes a long way 210 00:07:49,155 --> 00:07:50,762 to once and for all stop 211 00:07:50,829 --> 00:07:52,512 these profit-seeking food vendors 212 00:07:52,571 --> 00:07:55,539 from harming our nation's children. 213 00:07:55,572 --> 00:07:57,341 - That lady is good. - Giselle Overman has 214 00:07:57,366 --> 00:08:00,106 become a voice in this country for people without a voice. 215 00:08:00,275 --> 00:08:01,981 Her petit mal seizures have increased 216 00:08:02,018 --> 00:08:03,852 in intensity and frequency to the point where 217 00:08:03,877 --> 00:08:05,942 she no longer can function in her daily life. 218 00:08:06,022 --> 00:08:07,721 What can we do? I call it 219 00:08:07,746 --> 00:08:10,200 the neural pacemaker. 220 00:08:10,567 --> 00:08:13,360 I borrowed technology from the cardiac pacemaker. 221 00:08:13,583 --> 00:08:14,918 The neural pacemaker 222 00:08:14,958 --> 00:08:16,911 monitors electrical activity in the brain. 223 00:08:17,020 --> 00:08:18,221 When the cluster of neurons 224 00:08:18,223 --> 00:08:20,817 responsible for a seizure start to show increased activity, 225 00:08:20,872 --> 00:08:21,927 it basically 226 00:08:21,972 --> 00:08:24,184 snuffs out the seizure before it occurs. 227 00:08:24,442 --> 00:08:25,730 Be still my heart. 228 00:08:25,755 --> 00:08:27,030 When can we install that puppy? 229 00:08:27,032 --> 00:08:28,065 There's a hitch. 230 00:08:28,106 --> 00:08:29,458 I've done a functional MRI, 231 00:08:29,536 --> 00:08:30,978 a diffusion MRI and an EEG, 232 00:08:31,003 --> 00:08:32,083 and I haven't been able 233 00:08:32,121 --> 00:08:33,718 to isolate the area of her brain where 234 00:08:33,719 --> 00:08:35,177 the seizure cascade begins. 235 00:08:35,294 --> 00:08:37,677 So we have a fix, but without a seizure focus, 236 00:08:37,732 --> 00:08:39,544 we can't use it. How do we find the focus? 237 00:08:39,610 --> 00:08:42,153 Without a new way to look at the brain, I have no idea. 238 00:08:42,238 --> 00:08:44,104 So find a new way to look at the brain. 239 00:08:44,153 --> 00:08:45,552 (Laughs): Obviously. 240 00:08:45,706 --> 00:08:47,325 (Chuckles) 241 00:08:47,434 --> 00:08:48,442 Obviously. 242 00:08:48,524 --> 00:08:50,723 Cheng: These are projections of Maddie's cancer cells 243 00:08:50,810 --> 00:08:51,993 from the Bone Marrow you collected. 244 00:08:52,017 --> 00:08:53,637 So that protein is the lock. 245 00:08:53,713 --> 00:08:56,880 Exactly. But we're working on a key. The problem is 246 00:08:56,997 --> 00:08:58,794 the Leukemia protein has a similar structure 247 00:08:58,825 --> 00:09:00,278 to a lot of the other proteins in the body, 248 00:09:00,302 --> 00:09:01,934 so making our key fit that lock 249 00:09:01,959 --> 00:09:04,559 and only that lock hasn't been easy. - Hmm. 250 00:09:04,584 --> 00:09:05,769 Elody, how's it going? 251 00:09:05,794 --> 00:09:07,819 I can show you something in one minute. 252 00:09:09,677 --> 00:09:12,591 So, how's the Malik Sitch? 253 00:09:13,278 --> 00:09:14,449 (Whispers): He asked me to dinner. 254 00:09:14,473 --> 00:09:16,316 - And? - I panicked... I said brunch. 255 00:09:16,341 --> 00:09:18,652 Ooh. The brunch downgrade. Been there. 256 00:09:18,933 --> 00:09:21,745 Exactly. I just thought, take it slow, you know? 257 00:09:21,785 --> 00:09:23,735 It's not like a date or anything... it's brunch, 258 00:09:23,737 --> 00:09:25,537 it's casual. Please, I don't care 259 00:09:25,539 --> 00:09:27,589 if it's a five-course meal or an egg mcmuffin... 260 00:09:27,644 --> 00:09:29,855 Once food is being ingested, it's a date. 261 00:09:29,949 --> 00:09:31,378 So you're saying I shouldn't go to brunch? 262 00:09:31,402 --> 00:09:32,861 No, I'm saying you're going on a date. 263 00:09:32,885 --> 00:09:33,951 Elody: Yeah, I agree. 264 00:09:34,003 --> 00:09:35,613 It's definitely a date. Here, 265 00:09:35,696 --> 00:09:36,933 check this out. 266 00:09:38,956 --> 00:09:42,058 So, these are Maddie's T-Cells, which we've modified 267 00:09:42,105 --> 00:09:44,370 by adding our Artificial Antibody Detector. 268 00:09:44,425 --> 00:09:46,213 The blue ones are her modified T-Cells, 269 00:09:46,238 --> 00:09:48,964 and the red ones are her Leukemia cells. 270 00:09:49,347 --> 00:09:50,964 Oh, my God. 271 00:09:52,167 --> 00:09:53,683 This might actually work. 272 00:09:53,800 --> 00:09:54,710 Maddie: So... 273 00:09:54,735 --> 00:09:57,628 You're infusing me with some kind of GMO, 274 00:09:57,738 --> 00:10:00,644 which means if this works and, you know, I actually live, 275 00:10:00,691 --> 00:10:03,108 I will never be able to walk into a whole foods again. 276 00:10:03,110 --> 00:10:06,574 Not exactly. Um, these are your actual cells. 277 00:10:06,714 --> 00:10:09,347 We're just giving them the enhanced ability 278 00:10:09,394 --> 00:10:10,902 to detect your Lleukemia cells. 279 00:10:10,956 --> 00:10:13,402 - Hmm. - So, super cells. 280 00:10:13,581 --> 00:10:14,894 Yeah, super cells. 281 00:10:15,027 --> 00:10:18,468 Do your work, super cells. 282 00:10:21,572 --> 00:10:22,745 You ready to pick a little? 283 00:10:22,770 --> 00:10:24,119 Pick? Oh, yeah, no. 284 00:10:24,144 --> 00:10:26,111 Uh, not a picker. 285 00:10:26,161 --> 00:10:27,535 Then I'll play, you sing. 286 00:10:27,561 --> 00:10:29,113 (Exhales): No. (Laughing) 287 00:10:29,212 --> 00:10:31,285 Maddie, I don't think that's a good idea 288 00:10:31,340 --> 00:10:33,136 for anyone involved. 289 00:10:33,161 --> 00:10:34,089 Dr. Brockett, 290 00:10:34,114 --> 00:10:35,714 I have been to... 291 00:10:35,851 --> 00:10:38,394 Five hospitals in four different cities 292 00:10:38,499 --> 00:10:40,566 over the past two years. 293 00:10:40,658 --> 00:10:43,019 I mean, my life has just been about staying alive. 294 00:10:43,141 --> 00:10:44,425 So whenever 295 00:10:44,450 --> 00:10:46,517 someone sticks a needle in me 296 00:10:46,601 --> 00:10:47,831 or does a scan 297 00:10:47,875 --> 00:10:49,628 or pokes me or prods me, 298 00:10:49,769 --> 00:10:52,703 doing music is what gets me through it. 299 00:10:53,705 --> 00:10:56,136 So I'm afraid I'm gonna have to insist. 300 00:10:56,238 --> 00:10:58,541 ♪ ♪ 301 00:10:58,543 --> 00:11:00,910 I promise you you're gonna regret this. 302 00:11:00,912 --> 00:11:03,746 (Chuckling): Uh-huh. Mm-hmm. 303 00:11:03,748 --> 00:11:07,164 ♪ If you are falling ♪ 304 00:11:07,232 --> 00:11:11,125 ♪ Then I would catch you ♪ catch... oh, I can't. 305 00:11:11,266 --> 00:11:14,934 ♪ If you need a light ♪ 306 00:11:15,460 --> 00:11:18,825 (Both singing) ♪ I'd find a match ♪ 307 00:11:18,894 --> 00:11:21,160 ♪ 'Cause I ♪ 308 00:11:21,232 --> 00:11:26,302 ♪ Love the way you say good morning ♪ 309 00:11:26,345 --> 00:11:31,415 ♪ And you take me the way I am ♪ 310 00:11:31,538 --> 00:11:34,102 Maddie: Mm-hmm! Okay. 311 00:11:34,212 --> 00:11:37,580 ♪ If you are chilly ♪ 312 00:11:37,848 --> 00:11:41,688 ♪ Here, take my sweater ♪ 313 00:11:41,786 --> 00:11:45,469 ♪ If your head is aching ♪ 314 00:11:45,574 --> 00:11:48,975 ♪ I'll make it better ♪ 315 00:11:49,084 --> 00:11:50,998 ♪ 'Cause I ♪ 316 00:11:51,081 --> 00:11:53,850 ♪ Love the way ♪ 317 00:11:53,951 --> 00:11:56,209 ♪ You call me baby ♪ 318 00:11:56,345 --> 00:12:01,381 ♪ And you take me the way I am ♪ 319 00:12:01,513 --> 00:12:03,397 Oh, wow. 320 00:12:03,548 --> 00:12:06,194 Okay, this takes me back to the old days. 321 00:12:06,274 --> 00:12:08,291 Does it kind of remind you of the office they gave me 322 00:12:08,315 --> 00:12:10,850 when I was a surgical intern at the Cleveland Clinic? 323 00:12:10,940 --> 00:12:12,239 Mm-hmm. I remember 324 00:12:12,304 --> 00:12:14,413 showing up at midnight, because if I didn't 325 00:12:14,445 --> 00:12:15,920 I would never get to see you. 326 00:12:15,975 --> 00:12:18,178 If I recall, some of those visits 327 00:12:18,265 --> 00:12:20,432 weren't half bad. - Mmm. 328 00:12:20,809 --> 00:12:23,776 I think I figured out how... 329 00:12:24,028 --> 00:12:25,061 (Laughs) 330 00:12:25,063 --> 00:12:26,397 I am so sorry. I'll come back. 331 00:12:26,476 --> 00:12:28,381 No, it's okay. This is my wife, Julianna. 332 00:12:28,483 --> 00:12:30,373 Jules, this is Dr. Channarayapatra, 333 00:12:30,409 --> 00:12:32,631 my, um, office mate. (Door closes) 334 00:12:32,678 --> 00:12:34,319 Oh. Uh, Dr...? 335 00:12:34,390 --> 00:12:36,623 Channarayapatra. Oh, it's-it's... 336 00:12:36,648 --> 00:12:37,553 It's wonderful to meet you. 337 00:12:37,578 --> 00:12:39,608 I have heard so much about you and the kids. 338 00:12:39,645 --> 00:12:41,312 Oh, thank you. 339 00:12:42,022 --> 00:12:43,631 I will leave you two, to, uh... 340 00:12:43,656 --> 00:12:44,538 To carry on. 341 00:12:44,592 --> 00:12:46,116 (Laughing): Find me later. 342 00:12:46,141 --> 00:12:47,959 Please, this is your office; It's... well, 343 00:12:48,008 --> 00:12:49,475 it's both of your offices, right? 344 00:12:49,526 --> 00:12:50,803 So, please, go ahead. 345 00:12:50,914 --> 00:12:52,748 Okay. 346 00:12:53,114 --> 00:12:55,181 I was just thinking, 347 00:12:55,347 --> 00:12:57,381 maybe we don't actually need to find a new way 348 00:12:57,491 --> 00:13:00,030 of imaging the brain. We need a new way 349 00:13:00,071 --> 00:13:02,850 to process the data we've already gotten from the brain. 350 00:13:03,015 --> 00:13:04,077 So what if we took 351 00:13:04,117 --> 00:13:07,092 the FMRI, which localizes brain functions and laid it... 352 00:13:07,171 --> 00:13:08,530 Laid it over the EEG, 353 00:13:08,576 --> 00:13:10,873 which would give us a picture of the seizure activity. 354 00:13:10,998 --> 00:13:12,676 That should point us to the right area of the brain. 355 00:13:12,700 --> 00:13:14,700 Exactly. And if we merged that composite image 356 00:13:14,766 --> 00:13:16,233 with the diffusion tensor MRI, 357 00:13:16,305 --> 00:13:18,147 we should be able to follow the neural pathway 358 00:13:18,209 --> 00:13:19,647 back to the seizure focus. 359 00:13:19,717 --> 00:13:21,915 Both: Then we could see the seizure manifest 360 00:13:21,940 --> 00:13:24,332 itself in real time in three dimensions. 361 00:13:24,408 --> 00:13:25,516 This is brilliant. 362 00:13:25,541 --> 00:13:27,092 Sounds like writing some tricky software. 363 00:13:27,116 --> 00:13:28,032 Channarayapatra: I'll talk to James. 364 00:13:28,057 --> 00:13:29,399 He could do it in his sleep. 365 00:13:29,447 --> 00:13:32,094 - It's great to meet you. - Oh, you, too. 366 00:13:41,518 --> 00:13:44,623 Just... just tell us if it isn't working. 367 00:13:44,913 --> 00:13:46,467 We can handle bad news. 368 00:13:46,600 --> 00:13:48,233 It's good news. 369 00:13:48,912 --> 00:13:51,061 Wait. It is? Really? 370 00:13:51,194 --> 00:13:53,535 In fact, it's looking a little bit like a Christmas miracle. 371 00:13:53,559 --> 00:13:54,614 (Laughing): Oh, my God. 372 00:13:54,639 --> 00:13:55,983 Her numbers improved? 373 00:13:56,123 --> 00:13:57,897 These are your latest numbers. 374 00:13:57,998 --> 00:13:59,967 Your white cell count is 11,000. 375 00:14:00,037 --> 00:14:01,787 11,000? 376 00:14:01,863 --> 00:14:03,623 Are you serious? (Laughing) Oh, my God. 377 00:14:03,694 --> 00:14:05,451 I was at 45,000. 378 00:14:05,507 --> 00:14:07,474 Nothing we've done has ever brought 379 00:14:07,539 --> 00:14:09,549 her white cell count down. This is far better and faster 380 00:14:09,573 --> 00:14:11,240 than anything we could have ever imagined. 381 00:14:11,306 --> 00:14:12,972 Oh, my God. 382 00:14:16,553 --> 00:14:17,647 See? 383 00:14:17,683 --> 00:14:19,311 It was because you sang with me. 384 00:14:19,336 --> 00:14:21,295 (Laughing): I mean, you're my good luck charm. 385 00:14:21,416 --> 00:14:22,725 (Laughing): No, I'm not. 386 00:14:22,803 --> 00:14:24,284 (Laughter) 387 00:14:24,342 --> 00:14:26,419 Oh, baby. 388 00:14:29,959 --> 00:14:31,493 You guys are the best. 389 00:14:36,621 --> 00:14:38,217 Uh, James. 390 00:14:38,748 --> 00:14:40,756 Uh, not to get ahead of ourselves, 391 00:14:40,818 --> 00:14:42,482 but there's a concert coming up in a couple of weeks, 392 00:14:42,506 --> 00:14:44,326 Phillip Phillips is playing. 393 00:14:44,451 --> 00:14:46,883 He's been a huge hero to Maddie throughout all of this. 394 00:14:46,998 --> 00:14:48,358 I want to buy tickets, 395 00:14:48,421 --> 00:14:50,487 but I need to know if there's any way you think 396 00:14:50,512 --> 00:14:53,170 she's gonna be strong enough to go. 397 00:14:54,045 --> 00:14:56,100 Don't buy the tickets. 398 00:14:56,295 --> 00:14:57,155 Okay. 399 00:14:57,186 --> 00:14:58,618 Let me. 400 00:14:58,620 --> 00:15:00,286 (Chuckles) 401 00:15:00,350 --> 00:15:02,250 (Exhales) 402 00:15:08,599 --> 00:15:12,193 I hear the FDA is here to rule on the treatment 403 00:15:12,224 --> 00:15:14,202 for GSS. - Yes. 404 00:15:14,554 --> 00:15:17,541 What are the chances of getting approved? 405 00:15:19,772 --> 00:15:22,569 I feel our chances are sky-high, Louis. 406 00:15:22,811 --> 00:15:24,814 (Laughing) 407 00:15:26,108 --> 00:15:30,179 Bishop to queen's rook five. 408 00:15:32,657 --> 00:15:34,724 (Louis laughing) 409 00:15:38,100 --> 00:15:40,514 Louis, the bishop doesn't move that way. 410 00:15:40,710 --> 00:15:42,389 It moves diagonally. 411 00:15:49,772 --> 00:15:52,514 GSS is caused by abnormally folded proteins 412 00:15:52,561 --> 00:15:54,421 called Prions building up in the brain. 413 00:15:54,498 --> 00:15:56,240 These prions stick together in clusters 414 00:15:56,272 --> 00:15:57,811 called Oligomeric Aggregates, 415 00:15:57,865 --> 00:15:59,569 which are toxic to brain cells. 416 00:15:59,594 --> 00:16:01,007 We've been working on a new medication 417 00:16:01,031 --> 00:16:03,393 called PAI 120b. 418 00:16:03,440 --> 00:16:05,573 It's a Prion Aggregate inhibitor. 419 00:16:05,658 --> 00:16:07,862 This drug sticks to these abnormal Prion proteins 420 00:16:07,910 --> 00:16:10,596 so they can't clump together in these toxic aggregates. 421 00:16:10,677 --> 00:16:11,863 Cheng: We've been producing it right here 422 00:16:11,887 --> 00:16:13,533 in our pharmacologic sciences lab. 423 00:16:13,594 --> 00:16:15,299 It's in compliance with all FDA standards. 424 00:16:15,416 --> 00:16:18,729 Our patient, Louis Keating, is getting worse. 425 00:16:18,852 --> 00:16:20,783 This disease is attacking his body and his mind, 426 00:16:20,808 --> 00:16:21,653 and before long, 427 00:16:21,678 --> 00:16:23,401 even his shadow of an existence 428 00:16:23,471 --> 00:16:24,526 will come to an end. 429 00:16:24,585 --> 00:16:26,886 But our drug has a chance to change all that. 430 00:16:26,982 --> 00:16:29,010 Worst case scenario, this is a huge leap 431 00:16:29,074 --> 00:16:30,862 towards curing this insidious illness. 432 00:16:30,908 --> 00:16:32,441 Best case scenario, 433 00:16:33,002 --> 00:16:35,026 we give a man his life back. 434 00:16:36,612 --> 00:16:40,463 I-I mean, this is just a remarkable presentation. 435 00:16:40,666 --> 00:16:42,510 It-It's one of the strongest applications 436 00:16:42,540 --> 00:16:43,518 I've seen for a phase one 437 00:16:43,562 --> 00:16:44,879 clinical drug trial. Bell: Great. 438 00:16:44,905 --> 00:16:46,371 So we can move towards human trials. 439 00:16:46,420 --> 00:16:48,394 But it's not ready yet. 440 00:16:48,496 --> 00:16:50,050 You have eight weeks of safety data 441 00:16:50,094 --> 00:16:51,135 in your animal models, 442 00:16:51,160 --> 00:16:53,769 and I totally agree the numbers are really promising, 443 00:16:53,813 --> 00:16:55,488 but, James, that's only eight weeks. 444 00:16:55,530 --> 00:16:57,777 But we have a patient here who has an urgent need. 445 00:16:57,852 --> 00:16:59,293 I'm sorry. 446 00:16:59,419 --> 00:17:01,271 I need more data from the animal models 447 00:17:01,302 --> 00:17:03,271 for approval of a human trial. 448 00:17:03,420 --> 00:17:06,896 You're looking at six to 12 months, at least. 449 00:17:06,988 --> 00:17:09,732 ♪ ♪ 450 00:17:14,035 --> 00:17:16,629 This is for you. 451 00:17:16,896 --> 00:17:18,316 Hmm. 452 00:17:24,212 --> 00:17:26,228 Oh, my God. 453 00:17:26,763 --> 00:17:29,251 These are first row tickets to Phillip Phillips. 454 00:17:29,400 --> 00:17:30,525 Mm-hmm. 455 00:17:30,601 --> 00:17:32,423 (Chuckles) 456 00:17:32,681 --> 00:17:33,814 No. 457 00:17:33,995 --> 00:17:35,697 And backstage passes? 458 00:17:35,759 --> 00:17:37,501 Mm-hmm. But how did you know? 459 00:17:37,563 --> 00:17:39,353 Your dad told me. 460 00:17:39,563 --> 00:17:41,403 Wait, so you think I'll actually be able to go? 461 00:17:41,440 --> 00:17:42,472 I'm very hopeful. 462 00:17:42,498 --> 00:17:44,697 Oh, my God. 463 00:17:45,447 --> 00:17:47,197 Do you know what I was just doing? - No. 464 00:17:47,294 --> 00:17:49,528 I was writing a song. 465 00:17:49,827 --> 00:17:52,928 I mean, I-I stopped writing songs five months ago, 466 00:17:52,968 --> 00:17:55,322 because what was the point, you know? 467 00:17:55,509 --> 00:17:59,236 But for the first time in so long, 468 00:17:59,290 --> 00:18:02,298 I can actually see past being a patient. 469 00:18:02,665 --> 00:18:03,845 So... 470 00:18:03,915 --> 00:18:04,994 Tell me, Maddie, 471 00:18:05,034 --> 00:18:06,392 what's in your five-year plan? 472 00:18:06,486 --> 00:18:08,836 I have this stupid fantasy, 473 00:18:08,890 --> 00:18:10,218 really, that one day, 474 00:18:10,309 --> 00:18:12,578 I'll open up for Phillip Phillips 475 00:18:12,710 --> 00:18:14,743 and, you know, he'd invite me 476 00:18:14,745 --> 00:18:16,300 onstage and we'd sing a song. 477 00:18:16,401 --> 00:18:17,354 (Chuckles) 478 00:18:17,379 --> 00:18:20,206 ♪ Just know you're not alone ♪ 479 00:18:20,418 --> 00:18:23,805 ♪ 'Cause I'm gonna make this place your home. ♪ 480 00:18:23,842 --> 00:18:25,798 - Sorry. I know it's so dumb. - Nah. 481 00:18:25,829 --> 00:18:27,523 Sorry. It's not dumb at all. 482 00:18:27,525 --> 00:18:29,313 I really should go to a concert some day. 483 00:18:29,352 --> 00:18:31,891 - You've never been to a concert before? - Not really. 484 00:18:31,925 --> 00:18:34,392 - How is that even possible? - I don't know. 485 00:18:34,432 --> 00:18:36,352 I always thought I wanted to go see beta band, 486 00:18:36,415 --> 00:18:37,514 but then, uh, 487 00:18:37,594 --> 00:18:41,463 I heard they broke up. (Both laugh) 488 00:18:41,504 --> 00:18:44,238 So what's your five-year plan, then? 489 00:18:44,381 --> 00:18:47,160 You know, after you've saved everyone's life on the planet. 490 00:18:47,244 --> 00:18:48,764 What are you gonna do then, James bell? 491 00:18:48,879 --> 00:18:51,895 Well, I guess if you're really asking, uh... 492 00:18:53,012 --> 00:18:54,783 When I was a kid, I'd walk through my neighborhood 493 00:18:54,785 --> 00:18:55,590 and I'd look through the windows, 494 00:18:55,641 --> 00:18:56,887 and I'd see all these families 495 00:18:56,912 --> 00:18:59,090 gathered together around the TV, and I thought, 496 00:18:59,707 --> 00:19:01,481 that looks really beautiful. - Mmm. 497 00:19:01,546 --> 00:19:04,314 My mom used to work a lot, and, uh, 498 00:19:04,457 --> 00:19:06,090 when she was home 499 00:19:06,165 --> 00:19:09,582 we could never agree on a TV show. 500 00:19:09,808 --> 00:19:12,342 So I watched alone. 501 00:19:13,535 --> 00:19:15,356 So I guess when I grow up, what I want 502 00:19:15,458 --> 00:19:19,293 is... to have a family to watch TV with. 503 00:19:19,551 --> 00:19:21,340 Do you have someone to do that with? 504 00:19:21,606 --> 00:19:24,418 No. (Laughs) 505 00:19:24,702 --> 00:19:27,035 I mean... uh... 506 00:19:27,395 --> 00:19:29,684 I have this stupid idea, but... 507 00:19:29,895 --> 00:19:32,629 But what? 508 00:19:33,254 --> 00:19:35,387 I wouldn't even know where to start. 509 00:19:35,505 --> 00:19:39,107 Well, maybe start with what you just said, 510 00:19:39,390 --> 00:19:41,590 because it was awesome. 511 00:19:42,980 --> 00:19:44,325 Bell: Brockett. 512 00:19:44,350 --> 00:19:45,910 James. 513 00:19:45,966 --> 00:19:47,332 I've never been to a concert. 514 00:19:47,451 --> 00:19:48,559 - Oh? - Ever. 515 00:19:48,614 --> 00:19:49,832 I don't know why, I like music. 516 00:19:49,856 --> 00:19:51,863 I just... like to be able to hear the song 517 00:19:51,895 --> 00:19:53,308 that I want to hear when I want to hear it. 518 00:19:53,332 --> 00:19:54,582 The idea of having to watch a band 519 00:19:54,606 --> 00:19:56,371 and hope that they play the song I want to hear 520 00:19:56,395 --> 00:19:57,809 just seems so frustrating. 521 00:19:57,895 --> 00:19:59,051 (Chuckles) (Sighs) 522 00:19:59,076 --> 00:20:00,510 What if I'm sitting next to some drunk person 523 00:20:00,534 --> 00:20:01,867 who keeps trying to lean on me? 524 00:20:01,900 --> 00:20:03,973 Or someone who has to sing along to every word 525 00:20:04,004 --> 00:20:04,776 at the top of their lungs? 526 00:20:04,801 --> 00:20:06,722 You know, James, if you're not enjoying a concert 527 00:20:06,746 --> 00:20:08,387 you can always just leave. 528 00:20:08,466 --> 00:20:09,901 This has nothing to do with concerts, Brockett. 529 00:20:09,925 --> 00:20:11,771 - Oh, it doesn't? - Concerts is just one example. 530 00:20:11,795 --> 00:20:13,629 I'm talking about life. 531 00:20:13,666 --> 00:20:15,207 About watching TV with your family. 532 00:20:15,243 --> 00:20:17,910 About have a family to watch TV with. 533 00:20:18,326 --> 00:20:19,926 Life's short, Brockett, so short. 534 00:20:19,996 --> 00:20:22,775 And I've waited so long, too long. 535 00:20:22,822 --> 00:20:25,650 James, you're really not making any sense right now. 536 00:20:27,629 --> 00:20:29,400 I want to go to a concert with you, Brockett. 537 00:20:29,487 --> 00:20:31,876 - What? - I want to go out with you to a concert. 538 00:20:31,993 --> 00:20:33,697 You know, like on a date. 539 00:20:35,439 --> 00:20:37,198 - I get if I'm your boss...? - No, it's not that. 540 00:20:37,222 --> 00:20:40,697 I just, um... oh, I did... I didn't know, James. 541 00:20:40,752 --> 00:20:43,142 I... I didn't know. 542 00:20:43,986 --> 00:20:44,947 And? 543 00:20:44,972 --> 00:20:47,873 And, u-um... 544 00:20:48,259 --> 00:20:49,665 (Sighs) 545 00:20:49,751 --> 00:20:50,999 I'm really sorry, James, 546 00:20:51,001 --> 00:20:52,100 but I can't. 547 00:21:03,773 --> 00:21:05,048 James. 548 00:21:05,101 --> 00:21:06,101 Not now, W. 549 00:21:06,133 --> 00:21:08,415 Just need a minute. 550 00:21:08,671 --> 00:21:11,532 I'm attempting to write a multi-modal imaging program 551 00:21:11,615 --> 00:21:13,656 that merges three unique computer languages 552 00:21:13,754 --> 00:21:16,344 in the hopes of increasing image clarity down to a tenth 553 00:21:16,370 --> 00:21:18,984 of a millimeter to avoid frying Giselle overman's brain. 554 00:21:19,037 --> 00:21:20,704 Does it sound like I have a minute? 555 00:21:21,351 --> 00:21:23,406 Well, when you do have a minute... 556 00:21:23,469 --> 00:21:24,735 Damn it! 557 00:21:26,869 --> 00:21:28,870 Keyboard! Okay. 558 00:21:33,209 --> 00:21:34,599 (Sniffles) 559 00:21:35,310 --> 00:21:37,513 (Clears his throat) 560 00:21:37,677 --> 00:21:39,607 I apologize. 561 00:21:39,994 --> 00:21:42,795 That was very immature. 562 00:21:43,696 --> 00:21:45,763 Man: James? 563 00:21:48,351 --> 00:21:51,193 Thank you. Sorry for yelling. 564 00:21:55,851 --> 00:21:58,405 I want to run some tests. I'll need you to fast tonight. 565 00:21:58,430 --> 00:22:01,452 We'll run some blood work and I'll schedule an MRI, okay? 566 00:22:01,507 --> 00:22:04,476 - Okay. - We don't know anything yet, James. 567 00:22:04,952 --> 00:22:06,710 We don't need to panic. 568 00:22:06,898 --> 00:22:08,077 Debatable. 569 00:22:11,513 --> 00:22:13,287 Maddie: I can't believe James did that. I mean, 570 00:22:13,311 --> 00:22:16,218 the first-row tickets, the backstage passes. 571 00:22:16,281 --> 00:22:18,348 It's amazing. 572 00:22:18,929 --> 00:22:19,835 So... 573 00:22:19,917 --> 00:22:22,874 - Do you know who it is? - Do I know who what is? 574 00:22:23,427 --> 00:22:26,436 James kind of hinted that there was someone he was into. 575 00:22:27,230 --> 00:22:28,686 So, do you? 576 00:22:29,738 --> 00:22:31,972 No, I don't. 577 00:22:32,796 --> 00:22:34,288 Lucky girl. 578 00:22:34,313 --> 00:22:36,976 Yeah, she is. 579 00:22:42,046 --> 00:22:43,852 When did you start having bleeding in your gums? 580 00:22:43,876 --> 00:22:46,076 Uh, last night, when I was brushing my teeth. 581 00:22:46,279 --> 00:22:47,523 It's just a little bit of spotting. 582 00:22:47,547 --> 00:22:49,569 I haven't been to the dentist in a while. 583 00:22:49,662 --> 00:22:51,936 Start on 4.5 grams of I V Pip-Tazo 584 00:22:51,975 --> 00:22:53,255 every eight hours and hang a unit 585 00:22:53,279 --> 00:22:56,246 of Aphaeresis Platelets. - Yes, Dr. Brockett. 586 00:22:56,780 --> 00:22:58,585 Is everything okay? 587 00:22:58,740 --> 00:23:01,408 Yeah. Just want to be thorough. 588 00:23:02,898 --> 00:23:04,799 She's pancytopenic. 589 00:23:05,077 --> 00:23:07,351 The Car T destroyed a lot of the Lleukemia cells, 590 00:23:07,436 --> 00:23:09,632 but it's also targeting her healthy cell line. 591 00:23:09,788 --> 00:23:11,848 With all this collateral damage, she won't live long enough 592 00:23:11,872 --> 00:23:13,053 for us to get her into remission. 593 00:23:13,077 --> 00:23:14,517 Maybe we refine the antigen receptor. 594 00:23:14,585 --> 00:23:15,919 It was the only target we could find, 595 00:23:15,943 --> 00:23:17,280 and it had a lot of common antigens. 596 00:23:17,304 --> 00:23:19,108 I can't make the key any more specific. 597 00:23:19,172 --> 00:23:21,644 If we keep going with these treatments, we'll kill her. 598 00:23:21,796 --> 00:23:23,355 What are the other options? 599 00:23:27,810 --> 00:23:30,190 So, what, are we saying Maddie's gonna die, that's it? James, 600 00:23:30,214 --> 00:23:32,067 we all knew this was a Hail Mary Pass. 601 00:23:32,092 --> 00:23:33,784 W, I need you. 602 00:23:42,292 --> 00:23:44,417 It's happening, left hand this time. Right here, 603 00:23:44,480 --> 00:23:46,105 this spot. 604 00:23:46,574 --> 00:23:48,409 - Describe what you're feeling. - Tingling, 605 00:23:48,472 --> 00:23:50,409 not as strong as last time. 606 00:23:52,753 --> 00:23:54,433 Gone. 607 00:23:55,367 --> 00:23:56,870 It's over. 608 00:23:58,089 --> 00:24:00,352 I'm scared, W. 609 00:24:01,902 --> 00:24:03,603 Yeah, I know. 610 00:24:09,152 --> 00:24:12,446 - Okay, what's happening? - I have no idea. 611 00:24:12,714 --> 00:24:14,745 I do not accept that this girl is gonna die here. 612 00:24:14,796 --> 00:24:16,074 Not in our house. There is no such thing 613 00:24:16,098 --> 00:24:18,941 as a death sentence in Bunker Hill, so... ideas, 614 00:24:19,018 --> 00:24:20,902 pitches? Anything. Please. 615 00:24:20,981 --> 00:24:23,987 We just don't have anything else to offer at this point. 616 00:24:24,292 --> 00:24:25,362 At this point? At this 617 00:24:25,420 --> 00:24:27,245 specific moment in time, but maybe in a year, 618 00:24:27,277 --> 00:24:28,879 maybe in six months or maybe even a couple weeks 619 00:24:28,903 --> 00:24:30,856 we might have something better, right? - No, a couple of weeks 620 00:24:30,880 --> 00:24:32,433 is not a reason... - Am I correct? 621 00:24:34,402 --> 00:24:35,784 Yes. 622 00:24:36,542 --> 00:24:38,073 So what we need here is to buy time 623 00:24:38,098 --> 00:24:39,713 to find a cure that won't kill her. How do we buy time? 624 00:24:39,737 --> 00:24:41,214 James. Right now, 625 00:24:41,273 --> 00:24:43,948 she's at risk for continued infection, 626 00:24:43,980 --> 00:24:45,136 severe bleeding, 627 00:24:45,182 --> 00:24:47,902 anemia that could effect her organs and her heart. 628 00:24:47,963 --> 00:24:49,128 If her white cells 629 00:24:49,153 --> 00:24:52,064 get high enough... - Stop the negativity, please. 630 00:24:52,332 --> 00:24:56,000 What can we do to keep her alive? 631 00:24:56,534 --> 00:24:58,568 I suppose we could cover her with a broad spectrum 632 00:24:58,608 --> 00:25:01,099 of I V antibiotics... long term. 633 00:25:01,134 --> 00:25:03,052 And if we put in a central line, we can 634 00:25:03,232 --> 00:25:05,199 continue with regular blood and platelet transfusions. 635 00:25:05,201 --> 00:25:07,127 We need to support her anemia with oxygen. 636 00:25:07,232 --> 00:25:08,830 And if she has any respiratory distress, 637 00:25:08,916 --> 00:25:10,955 we could intubate her and put her on a ventilator. 638 00:25:11,014 --> 00:25:13,128 Think of what you'd be doing to her, putting her through. 639 00:25:13,152 --> 00:25:15,924 - Think about her family. - I'd be saving her life. 640 00:25:20,323 --> 00:25:21,518 Giselle: That's my brain? 641 00:25:21,584 --> 00:25:23,690 We combined three scans to create this image, 642 00:25:23,747 --> 00:25:25,625 and we were able to locate the source of your seizure. 643 00:25:25,649 --> 00:25:27,705 Dorothy, we're not in county anymore. 644 00:25:27,732 --> 00:25:30,872 Unfortunately, your seizure source is in your thalamus, 645 00:25:30,970 --> 00:25:33,286 deep in the brain. Close to the brain stem, 646 00:25:33,427 --> 00:25:36,028 near, uh, vital arteries. - Meaning? 647 00:25:36,155 --> 00:25:38,739 Meaning if we're even thinking about going in there we need 648 00:25:38,803 --> 00:25:40,864 zero margin for error. - So we set up 649 00:25:40,899 --> 00:25:43,083 a real-time interoperative imaging. 650 00:25:43,614 --> 00:25:47,193 Now Dr. channarayapatra can track electric impulses 651 00:25:47,242 --> 00:25:49,685 in the brain in real time during surgery. 652 00:25:49,766 --> 00:25:51,638 Like a deadly game of operation. 653 00:25:51,690 --> 00:25:53,513 This surgery isn't going to be easy, 654 00:25:53,636 --> 00:25:55,869 but we think we can get to it if we follow 655 00:25:55,925 --> 00:25:57,153 a carefully planned route. 656 00:25:57,184 --> 00:25:58,513 We do need you to understand, 657 00:25:58,555 --> 00:26:01,692 um, there is a real possibility 658 00:26:01,806 --> 00:26:02,810 you may not wake up 659 00:26:02,879 --> 00:26:04,946 from this surgery. 660 00:26:06,575 --> 00:26:10,397 I understand. It is frightening. 661 00:26:12,732 --> 00:26:15,903 I'm-I'm not upset because I'm scared. 662 00:26:17,023 --> 00:26:18,624 I'm moved. 663 00:26:19,277 --> 00:26:21,857 I'm willing to take the risk. 664 00:26:22,306 --> 00:26:25,380 I don't have kids. I-I don't have a husband. 665 00:26:25,715 --> 00:26:28,247 I have my clients. 666 00:26:28,863 --> 00:26:31,121 And what good am I if I can't help them? 667 00:26:31,468 --> 00:26:32,810 Thank you. 668 00:26:33,442 --> 00:26:34,855 Then, with your permission, 669 00:26:34,919 --> 00:26:36,028 we'd like to schedule this 670 00:26:36,053 --> 00:26:37,575 for tomorrow morning. 671 00:26:37,743 --> 00:26:39,935 Tomorrow morning. 672 00:26:40,649 --> 00:26:42,349 Merry Christmas, huh? 673 00:26:42,771 --> 00:26:44,739 - Let's do it. - Let's do it. 674 00:26:49,362 --> 00:26:50,896 I hope to hell this works. 675 00:26:50,973 --> 00:26:53,468 Oh, you'll do great. This will work. 676 00:26:54,411 --> 00:26:56,601 Dr. Wallace. 677 00:26:56,764 --> 00:26:58,543 This is the first time this kind of surgery's 678 00:26:58,568 --> 00:27:00,312 ever been attempted. 679 00:27:00,487 --> 00:27:02,788 I would be honored if you would scrub in with me. 680 00:27:02,945 --> 00:27:05,946 My wife just flew all the way out here to see me. 681 00:27:06,331 --> 00:27:07,866 Tomorrow's my only day off, so... 682 00:27:07,930 --> 00:27:10,476 Of course. You guys have fun. 683 00:27:10,541 --> 00:27:11,608 Yeah. 684 00:27:11,690 --> 00:27:13,327 Bring this one home, doctor. 685 00:27:13,439 --> 00:27:15,593 We could all use a win right now. 686 00:27:19,367 --> 00:27:22,608 ♪ ♪ 687 00:27:22,672 --> 00:27:28,160 ♪ I'll have a blue Christmas ♪ 688 00:27:28,230 --> 00:27:30,455 ♪ Without you ♪ 689 00:27:30,566 --> 00:27:33,760 Your cells built up a resistance 690 00:27:33,837 --> 00:27:35,674 to the Car T Cell therapy... 691 00:27:35,732 --> 00:27:38,353 ♪ Without you ♪ 692 00:27:38,439 --> 00:27:42,587 ♪ Decoration of red ♪ 693 00:27:42,681 --> 00:27:44,126 ♪ On a green ♪ 694 00:27:44,231 --> 00:27:47,707 ♪ Christmas tree ♪ 695 00:27:47,731 --> 00:27:49,825 ♪♪ 696 00:27:49,950 --> 00:27:51,855 So there's no chance of trying that again? 697 00:27:51,880 --> 00:27:54,066 ♪ Won't be the same dear ♪ 698 00:27:54,155 --> 00:27:56,676 ♪ If you're not here with me ♪ 699 00:27:56,765 --> 00:27:58,918 That strategy is no longer viable. 700 00:27:58,942 --> 00:28:00,973 ♪♪ 701 00:28:01,059 --> 00:28:04,350 ♪ And when those blue snowflakes ♪ 702 00:28:04,396 --> 00:28:05,653 We are meeting and talking 703 00:28:05,678 --> 00:28:07,748 and doing everything we can 704 00:28:07,843 --> 00:28:10,225 to try to find something that will work for you. 705 00:28:10,250 --> 00:28:13,461 ♪ That's when those blue memories ♪ 706 00:28:13,514 --> 00:28:16,209 ♪ Start calling ♪ 707 00:28:16,386 --> 00:28:20,089 ♪ You'll be doing all right ♪ 708 00:28:20,160 --> 00:28:22,303 ♪ With your Christmas ♪ 709 00:28:22,383 --> 00:28:25,983 ♪ Of white ♪ 710 00:28:26,053 --> 00:28:27,944 ♪♪ 711 00:28:27,969 --> 00:28:31,538 ♪ But I'll have a blue ♪ 712 00:28:31,540 --> 00:28:33,478 ♪ Blue Christmas ♪ 713 00:28:33,609 --> 00:28:35,008 (Lock beeps) 714 00:28:36,744 --> 00:28:39,228 What are you still doing here? 715 00:28:39,533 --> 00:28:40,845 Um... 716 00:28:40,970 --> 00:28:42,877 I'm gonna stay the night. 717 00:28:43,080 --> 00:28:44,658 Maddie's numbers don't look good. 718 00:28:44,772 --> 00:28:46,916 I don't want to be far. 719 00:28:47,611 --> 00:28:49,720 I hope your patients know how hard you work for them, 720 00:28:49,773 --> 00:28:51,009 Dr. Brockett. 721 00:28:51,111 --> 00:28:52,577 You okay? 722 00:28:53,971 --> 00:28:55,305 Yeah. 723 00:28:55,698 --> 00:28:57,439 Hey. 724 00:29:00,478 --> 00:29:01,845 What's going on? 725 00:29:02,150 --> 00:29:04,638 I was just thinking about my mom. 726 00:29:06,368 --> 00:29:07,939 She had cancer. 727 00:29:08,056 --> 00:29:09,767 Breast cancer. Came back 728 00:29:09,804 --> 00:29:12,072 three times, it spread everywhere. 729 00:29:14,372 --> 00:29:16,573 I was 14 when she died. 730 00:29:16,762 --> 00:29:20,431 That's when I decided to become a doctor. 731 00:29:20,723 --> 00:29:21,955 Somehow Maddie has just 732 00:29:22,019 --> 00:29:23,852 brought it all back to me... 733 00:29:24,228 --> 00:29:26,254 How helpless it feels. 734 00:29:29,780 --> 00:29:32,215 It's so unfair, Malik. 735 00:29:34,685 --> 00:29:36,322 Yeah. 736 00:29:37,407 --> 00:29:39,298 Sorry. This is so embarrassing. 737 00:29:39,556 --> 00:29:42,886 I'm a doctor, patients die. I just... No, hey, hey, come here. 738 00:29:43,535 --> 00:29:45,347 It's all right. 739 00:29:52,581 --> 00:29:54,649 You okay? 740 00:30:10,430 --> 00:30:11,430 Mmm. 741 00:30:11,574 --> 00:30:12,621 Good? 742 00:30:12,674 --> 00:30:14,285 - Wow, yeah. - I hope not too dry. 743 00:30:14,319 --> 00:30:15,933 - No, it's perfect. - Oh, good. 744 00:30:16,016 --> 00:30:19,254 Hardly done any cooking. I've been working crazy hours. 745 00:30:19,777 --> 00:30:22,199 Yeah. Um, that doctor... 746 00:30:22,269 --> 00:30:23,261 Channaray... 747 00:30:23,285 --> 00:30:24,496 - Channarayapatra. - Yeah. 748 00:30:24,521 --> 00:30:25,871 She mentioned that. 749 00:30:25,970 --> 00:30:27,699 She's really talented. 750 00:30:27,816 --> 00:30:30,527 - Yeah. - And a former Miss India. 751 00:30:30,597 --> 00:30:32,793 (Chuckles) I'm not kidding. 752 00:30:32,996 --> 00:30:34,879 She really was Miss India. 753 00:30:35,035 --> 00:30:35,996 For real. 754 00:30:36,028 --> 00:30:37,988 She was? 755 00:30:38,636 --> 00:30:39,800 According to Google. 756 00:30:39,886 --> 00:30:41,574 Why would you Google her? 757 00:30:41,647 --> 00:30:44,363 Oh, I don't know, Walt. Why would I do that? She's only 758 00:30:44,410 --> 00:30:47,535 a gorgeous and brilliant single heterosexual that you're 759 00:30:47,574 --> 00:30:50,152 sharing an office with and you never mentioned her. 760 00:30:50,228 --> 00:30:53,238 I never mentioned her because there's nothing to mention. 761 00:30:53,382 --> 00:30:55,660 - Mm. I see. 762 00:30:55,890 --> 00:30:58,246 Are you really upset by this? 763 00:30:59,582 --> 00:31:01,425 I'm not upset about her specifically, no. 764 00:31:01,450 --> 00:31:03,264 - Well, you're upset about something. - Okay, I'm upset. 765 00:31:03,288 --> 00:31:05,433 Maybe I-I think I'm upset because this started out 766 00:31:05,467 --> 00:31:08,394 as a job that you had to take. It was a stopgap measure 767 00:31:08,434 --> 00:31:09,832 because of what happened in Ohio, 768 00:31:09,890 --> 00:31:11,715 because you couldn't get a job anywhere else. 769 00:31:11,791 --> 00:31:14,158 And suddenly you're working all hours of the night 770 00:31:14,168 --> 00:31:15,496 and your sharing an office with... 771 00:31:15,629 --> 00:31:18,126 with a brilliant and exotic beauty queen. 772 00:31:18,340 --> 00:31:20,609 - Jules, I... - this is what I need to know: 773 00:31:20,711 --> 00:31:23,009 If you are so happy here... 774 00:31:23,234 --> 00:31:24,593 Where does that leave our family? 775 00:31:24,649 --> 00:31:27,016 Luke's going to college in a couple of months... - No, us! 776 00:31:27,065 --> 00:31:28,065 Where does it leave us? 777 00:31:28,113 --> 00:31:29,334 It leaves us in love 778 00:31:29,359 --> 00:31:31,343 with each other and working in different places. 779 00:31:31,484 --> 00:31:32,960 - People make it work. - Oh, all right. 780 00:31:32,984 --> 00:31:34,687 So then you've decided to stay. That's it. 781 00:31:34,718 --> 00:31:37,078 - I have not decided to stay. - Yes, you have, you have. 782 00:31:37,103 --> 00:31:40,218 You just... You don't know it yet. 783 00:31:40,365 --> 00:31:44,167 Fine. I do like it here. 784 00:31:44,669 --> 00:31:46,507 I like that Louis Keating has a rare disease 785 00:31:46,532 --> 00:31:48,848 that nobody cares about and we're fighting for him. 786 00:31:48,911 --> 00:31:50,887 I like that we don't just throw up our hands 787 00:31:50,955 --> 00:31:52,187 and say, "we give up." 788 00:31:52,259 --> 00:31:53,676 And this isn't some new me, 789 00:31:53,750 --> 00:31:55,872 this is the old me. The young, 790 00:31:55,933 --> 00:31:59,901 idealistic medical student that you fell in love with, Jules. 791 00:32:00,692 --> 00:32:02,778 And this is the man who risked my job 792 00:32:02,879 --> 00:32:05,413 to save that kid's life in Ohio. 793 00:32:16,698 --> 00:32:19,293 What are you doing here? 794 00:32:20,051 --> 00:32:21,114 I didn't want to wake you. 795 00:32:21,145 --> 00:32:23,973 That's only slightly creepy. 796 00:32:24,497 --> 00:32:26,239 I'm sorry. 797 00:32:30,031 --> 00:32:32,099 How are you feeling? 798 00:32:33,735 --> 00:32:36,337 They already explained things to me, James. 799 00:32:36,472 --> 00:32:37,738 I get it. 800 00:32:38,379 --> 00:32:40,030 You tried. 801 00:32:40,333 --> 00:32:41,692 And I love you for that. 802 00:32:41,760 --> 00:32:44,333 We have a plan. I want to keep you alive long enough 803 00:32:44,372 --> 00:32:46,653 to find a way to make this work. 804 00:32:46,717 --> 00:32:48,270 We came close. We can do this. 805 00:32:48,349 --> 00:32:50,200 What it will take will be a little drastic. 806 00:32:50,284 --> 00:32:51,528 And some discomfort. 807 00:32:51,607 --> 00:32:53,208 You'll need regular blood transfusions 808 00:32:53,264 --> 00:32:55,372 and possibly a feeding tube to help James, no. 809 00:32:55,397 --> 00:32:57,356 With nutrition... James, listen. 810 00:32:57,476 --> 00:32:59,645 And I need you to really listen to me, okay? 811 00:32:59,892 --> 00:33:00,895 Okay. 812 00:33:01,063 --> 00:33:03,096 I've waged my battle. 813 00:33:04,130 --> 00:33:06,575 You helped me do that. 814 00:33:07,115 --> 00:33:08,301 And I fought hard. 815 00:33:08,326 --> 00:33:10,934 I fought really, really hard. 816 00:33:11,010 --> 00:33:13,845 And I'm ready for whatever comes. 817 00:33:14,902 --> 00:33:16,340 I've made my peace. 818 00:33:16,440 --> 00:33:18,106 Okay, James? 819 00:33:18,864 --> 00:33:21,161 I don't know if I'm ready. 820 00:33:23,356 --> 00:33:25,481 How's your plan going? 821 00:33:25,872 --> 00:33:28,379 The one about watching TV with a family. 822 00:33:28,723 --> 00:33:30,950 Not... so great. 823 00:33:31,053 --> 00:33:32,686 Hmm. 824 00:33:33,556 --> 00:33:35,934 Okay. Well... 825 00:33:36,147 --> 00:33:39,575 Maybe you need to stop thinking about the big five-year plan 826 00:33:39,919 --> 00:33:42,020 and just start thinking one step ahead. 827 00:33:42,196 --> 00:33:43,348 You know? 828 00:33:43,534 --> 00:33:47,098 Like... go to a concert. 829 00:33:47,731 --> 00:33:49,947 And an actual concert, not for some band 830 00:33:49,972 --> 00:33:52,010 that broke up 1,000 years ago. 831 00:33:52,896 --> 00:33:55,131 Go to a concert right now. 832 00:33:57,163 --> 00:33:59,252 Live your life, James. 833 00:34:18,085 --> 00:34:20,286 ♪ ♪ 834 00:34:20,817 --> 00:34:22,956 Hey. 835 00:34:23,327 --> 00:34:26,428 Hi. 836 00:34:28,998 --> 00:34:30,878 Hey. 837 00:34:32,774 --> 00:34:33,673 Jules, 838 00:34:33,721 --> 00:34:36,691 um, can we just... Move past last night? 839 00:34:36,716 --> 00:34:38,363 This is our only day alone together. 840 00:34:38,445 --> 00:34:40,245 Yeah, I want that, too. 841 00:34:40,516 --> 00:34:42,699 Good. Well, if we leave soon, we'll beat traffic 842 00:34:42,724 --> 00:34:44,839 and be in San Francisco in a half hour? 843 00:34:44,908 --> 00:34:46,542 Uh, museums open at 10:00. 844 00:34:46,567 --> 00:34:47,863 Then the Golden Gate Park. 845 00:34:47,888 --> 00:34:49,472 I was gonna have James 846 00:34:49,498 --> 00:34:51,542 call in a favor and get us a table at Chez Panisse 847 00:34:51,614 --> 00:34:52,784 for lunch. 848 00:34:52,892 --> 00:34:55,120 Or we can do something else. 849 00:34:55,221 --> 00:34:57,355 You know, what I think I'd really like to see 850 00:34:57,435 --> 00:34:59,535 is, uh, Bunker Hill Hospital. 851 00:34:59,670 --> 00:35:00,887 Because I hear they're performing 852 00:35:00,911 --> 00:35:03,331 an amazing surgery there today. 853 00:35:03,942 --> 00:35:06,909 Show me the miracle, Walt. 854 00:35:07,265 --> 00:35:09,456 (Door opens) 855 00:35:12,150 --> 00:35:13,917 (Door closes) 856 00:35:16,032 --> 00:35:18,567 (Water running) 857 00:35:19,882 --> 00:35:21,769 What about your day with your wife? 858 00:35:21,849 --> 00:35:24,527 She couldn't miss this. 859 00:35:25,009 --> 00:35:26,341 Neither could I. 860 00:35:33,027 --> 00:35:35,495 (Steady beeping) 861 00:35:50,171 --> 00:35:53,504 Those are the thalamocortical radiations. 862 00:35:53,618 --> 00:35:54,816 The key determinants 863 00:35:54,896 --> 00:35:56,371 of consciousness. 864 00:35:56,404 --> 00:35:57,716 Wallace: If we know they're there, 865 00:35:57,740 --> 00:35:59,540 we know how to avoid them. 866 00:36:18,640 --> 00:36:20,052 I thought a lot about what I truly want 867 00:36:20,076 --> 00:36:21,387 my first concert to be. 868 00:36:21,427 --> 00:36:22,628 Part of me would go with the legends... 869 00:36:22,652 --> 00:36:24,699 Paul McCartney, the stones. 870 00:36:25,762 --> 00:36:26,793 Another part of me would 871 00:36:26,844 --> 00:36:28,349 just turn up to a little club on the haight, 872 00:36:28,373 --> 00:36:30,348 just watch some guy trying to make it. 873 00:36:30,464 --> 00:36:32,105 And then I thought it's probably less 874 00:36:32,130 --> 00:36:34,644 about who you're seeing and more about who you're with. 875 00:36:34,746 --> 00:36:38,777 So I decided I want my first concert to be with you. 876 00:36:40,496 --> 00:36:42,765 (Muffled shouting) 877 00:36:42,876 --> 00:36:44,902 Oh, my God. 878 00:36:45,033 --> 00:36:47,246 (Chuckling): Oh, my God. 879 00:36:47,553 --> 00:36:50,120 Heather, what are you doing here? 880 00:36:50,184 --> 00:36:51,973 Aunt Meg, hi! 881 00:36:52,058 --> 00:36:54,605 Oh! Hi, guys. I love you guys. 882 00:36:54,835 --> 00:36:57,027 H-how did all of this happen? 883 00:36:57,131 --> 00:36:58,207 It was all James. 884 00:36:58,232 --> 00:37:00,488 He sent a plane for everyone. 885 00:37:00,659 --> 00:37:01,808 James? 886 00:37:02,379 --> 00:37:06,452 (Guitar playing) 887 00:37:09,831 --> 00:37:12,653 ♪ Hold on ♪ 888 00:37:12,770 --> 00:37:15,020 ♪ To me as we go ♪ 889 00:37:15,139 --> 00:37:17,738 ♪ ♪ 890 00:37:17,851 --> 00:37:21,142 ♪ As we roll down ♪ 891 00:37:21,217 --> 00:37:26,053 ♪ This unfamiliar road ♪ 892 00:37:26,103 --> 00:37:29,869 ♪ And although this wave ♪ 893 00:37:29,971 --> 00:37:31,939 ♪ Is stringing us along ♪ 894 00:37:32,029 --> 00:37:33,119 Come on, help me out. 895 00:37:33,144 --> 00:37:34,878 (Chuckles) 896 00:37:34,939 --> 00:37:39,602 Maddie/phillip: ♪ just know you're not alone ♪ 897 00:37:39,667 --> 00:37:44,175 ♪ 'Cause I'm gonna make this place your home ♪ 898 00:37:44,230 --> 00:37:46,800 ♪♪ 899 00:37:46,918 --> 00:37:50,343 ♪ Settle down ♪ 900 00:37:50,484 --> 00:37:55,663 ♪ It'll all be clear ♪ 901 00:37:55,751 --> 00:37:58,710 ♪ Don't pay no mind to the demons ♪ 902 00:37:58,776 --> 00:38:01,577 ♪ They fill you with fear ♪ 903 00:38:01,601 --> 00:38:03,671 ♪♪ 904 00:38:03,766 --> 00:38:07,763 ♪ The trouble, it might drag you down ♪ 905 00:38:07,873 --> 00:38:09,067 ♪ If you get lost ♪ 906 00:38:09,106 --> 00:38:12,489 ♪ You can always be found ♪ 907 00:38:12,585 --> 00:38:17,488 ♪ Just know you're not alone ♪ 908 00:38:17,598 --> 00:38:21,786 ♪ 'Cause I'm gonna make this place your home ♪ 909 00:38:21,811 --> 00:38:24,333 ♪ ♪ 910 00:38:24,427 --> 00:38:28,929 ♪ Now, ooh... ♪ 911 00:38:28,954 --> 00:38:32,911 ♪ Ooh... ♪ 912 00:38:32,993 --> 00:38:39,065 ♪ Ah-ooh... ♪ 913 00:38:45,784 --> 00:38:48,089 The study wasn't approved. 914 00:38:56,503 --> 00:38:59,526 I won't stop fighting for you, Louis. 915 00:39:01,373 --> 00:39:04,808 Do you understand me? 916 00:39:05,217 --> 00:39:08,318 I will not give up. 917 00:39:09,497 --> 00:39:11,050 I'm fighting for you. 918 00:39:11,184 --> 00:39:13,769 I'm fighting for me, too. 919 00:39:16,982 --> 00:39:20,050 We're in this together, Louis. 920 00:39:21,138 --> 00:39:24,541 I might be running out of time, James. 921 00:39:28,742 --> 00:39:31,244 ♪ ♪ 922 00:39:50,484 --> 00:39:53,087 ♪ ♪ 923 00:39:53,156 --> 00:39:55,813 (Laughs) My mouth's bleedin', Bert! 924 00:39:55,894 --> 00:39:58,540 My mouth's bleed... Zuzu's petals. 925 00:39:58,668 --> 00:40:00,391 Zuzu... there they are! 926 00:40:00,527 --> 00:40:04,029 Bert, what do you know about that?! 927 00:40:10,760 --> 00:40:12,391 What are you doing here? 928 00:40:12,548 --> 00:40:14,391 I sent the team home. It's Christmas Eve. 929 00:40:14,416 --> 00:40:16,196 Your tests came back. 930 00:40:16,466 --> 00:40:19,040 Your tremors aren't from GSS. 931 00:40:19,384 --> 00:40:20,844 That Kombucha you're drinking, 932 00:40:20,869 --> 00:40:22,212 it's heavily caffeinated. 933 00:40:22,249 --> 00:40:24,688 Your tremors were probably a combination of sugar, 934 00:40:24,717 --> 00:40:27,266 caffeine, and too little sleep. 935 00:40:27,340 --> 00:40:29,829 Need to take care of yourself, okay? 936 00:40:30,657 --> 00:40:31,727 How's Giselle overman? 937 00:40:31,754 --> 00:40:33,594 Eight hours, no seizures. 938 00:40:33,982 --> 00:40:37,579 Already turned her recovery room into a temporary office. 939 00:40:37,879 --> 00:40:40,048 We did it, James. 940 00:40:40,675 --> 00:40:42,001 See? 941 00:40:42,071 --> 00:40:44,714 It is a wonderful life. 942 00:40:47,812 --> 00:40:49,547 Yeah. 943 00:40:49,750 --> 00:40:51,430 Merry Christmas, James. 944 00:40:51,638 --> 00:40:53,156 Merry Christmas. 945 00:40:54,776 --> 00:40:56,601 W? 946 00:40:58,795 --> 00:41:02,234 Will you sit with me for a few minutes? 947 00:41:03,345 --> 00:41:06,447 Sure, James. 948 00:41:08,773 --> 00:41:10,738 ♪ ♪ 949 00:41:10,855 --> 00:41:13,347 ♪ Have yourself ♪ 950 00:41:13,515 --> 00:41:18,115 ♪ A Merry little Christmas ♪ 951 00:41:18,209 --> 00:41:23,853 ♪ Let your heart be light ♪ 952 00:41:23,985 --> 00:41:26,536 ♪ From now on ♪ 953 00:41:26,614 --> 00:41:29,856 ♪ Our troubles will be out ♪ 954 00:41:29,933 --> 00:41:31,892 ♪ Of sight ♪ 955 00:41:31,925 --> 00:41:34,501 ♪ ♪ 956 00:41:34,541 --> 00:41:37,017 ♪♪ 957 00:41:37,148 --> 00:41:39,704 ♪ Have yourself ♪ 958 00:41:39,806 --> 00:41:44,447 ♪ A Merry little Christmas ♪ 959 00:41:44,556 --> 00:41:50,150 ♪ Make the yuletide gay ♪ 960 00:41:50,291 --> 00:41:53,030 ♪ From now on ♪ 961 00:41:53,032 --> 00:41:57,909 ♪ Our troubles will be far away... ♪ 962 00:41:57,956 --> 00:42:03,121 ♪ ♪ 963 00:42:03,199 --> 00:42:05,926 ♪ And here we are ♪ 964 00:42:05,998 --> 00:42:09,388 ♪ As in olden days ♪ 965 00:42:09,448 --> 00:42:12,622 ♪ Happy golden days ♪ 966 00:42:12,702 --> 00:42:16,567 ♪ Of yore ♪ 967 00:42:16,631 --> 00:42:19,427 ♪ Faithful friends ♪ 968 00:42:19,462 --> 00:42:22,463 ♪ Who are dear to us ♪ 969 00:42:22,504 --> 00:42:25,649 ♪ Gather near to us... ♪ 970 00:42:25,673 --> 00:42:28,641 ♪♪ 971 00:42:28,735 --> 00:42:32,302 ♪ Once more. ♪ 972 00:42:32,304 --> 00:42:35,272 (On TV): Merry Christmas! 973 00:42:35,274 --> 00:42:36,740 Merry Christmas! 974 00:42:36,742 --> 00:42:39,673 ♪♪ Merry Christmas! Precisely Synchronized by srjanapala